Epigenetic phenomena: Epigenetic phenomena: Paramutation and gene silencing in plants

Epigenetic phenomena: Epigenetic phenomena: Paramutation and gene silencing in plants

Gene silencing is a widespread phenomenon in plants, and can affect endogenous genes as well as transgenes integrated into the genome [1,2]. Gene silencing can be induced by interactions between related genes, and one of the best-known examples is named paramutation. Paramutation is the directed heritable alteration of one allele following exposure to another allele in a heterozygote [3]. Examp...

Epigenetic silencing in transgenic plants

Epigenetic silencing is a natural phenomenon in which the expression of genes is regulated through modifications of DNA, RNA, or histone proteins. It is a mechanism for defending host genomes against the effects of transposable elements and viral infection, and acts as a modulator of expression of duplicated gene family members and as a silencer of transgenes. A major breakthrough in understand...

Nickel and Epigenetic Gene Silencing

Insoluble nickel compounds are well-established human carcinogens. Occupational exposure to these compounds leads to increased incidence of lung and nasal cancer in nickel refinery workers. Apart from its weak mutagenic activity and hypoxia mimicking effect there is mounting experimental evidence indicating that epigenetic alteration plays an important role in nickel-induced carcinogenesis. Mul...

Epigenetic gene silencing in cancer.

Epigenetic phenomena in hormonally dependent malignancies in women — review

Hormonally dependent malignancies in women (endometrial tumors, ovarian and mammary glandcancers) areleading cause of death among women bearing malignant tumors.The steroid receptors (estrogen receptor — ER, and progesterone receptor — PR) status o he tumor, apart fromhistological grade of neoplasm differentiation and clinical stage, seems to be an important and valuableprognostic marker as far...